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Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrate

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global threat to human health has highlighted the need for the development of novel therapies targeting current and emerging coronaviruses with pandemic potential. The coronavirus main protease (M(pro), also called 3C...

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Detalles Bibliográficos
Autores principales: Legare, Scott, Heide, Fabian, Bailey-Elkin, Ben A., Stetefeld, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849842/
https://www.ncbi.nlm.nih.gov/pubmed/35182525
http://dx.doi.org/10.1016/j.jbc.2022.101739