SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show that in addition to ensuring H3K9me, MET-2, the Caenorhabditis elegans homolog of the SETDB1 histone methyltransferase...

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Detalles Bibliográficos
Autores principales: Delaney, Colin E., Methot, Stephen P., Kalck, Veronique, Seebacher, Jan, Hess, Daniel, Gasser, Susan M., Padeken, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850192/
https://www.ncbi.nlm.nih.gov/pubmed/35102319
http://dx.doi.org/10.1038/s41594-021-00712-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850192/
https://www.ncbi.nlm.nih.gov/pubmed/35102319
http://dx.doi.org/10.1038/s41594-021-00712-4

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