Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA

Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions(1–5), diffuse hypermutation termed omikli(6), and longer strand-coordinated events termed kataegis(3,7–9). H...

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Detalles Bibliográficos
Autores principales: Bergstrom, Erik N., Luebeck, Jens, Petljak, Mia, Khandekar, Azhar, Barnes, Mark, Zhang, Tongwu, Steele, Christopher D., Pillay, Nischalan, Landi, Maria Teresa, Bafna, Vineet, Mischel, Paul S., Harris, Reuben S., Alexandrov, Ludmil B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850194/
https://www.ncbi.nlm.nih.gov/pubmed/35140399
http://dx.doi.org/10.1038/s41586-022-04398-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850194/
https://www.ncbi.nlm.nih.gov/pubmed/35140399
http://dx.doi.org/10.1038/s41586-022-04398-6

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