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Exposure to GABA(A) Receptor Antagonist Picrotoxin in Pregnant Mice Causes Autism-Like Behaviors and Aberrant Gene Expression in Offspring

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interaction and restricted/repetitive behaviors. The neurotransmitter γ-aminobutyric acid (GABA) through GABA(A) receptor signaling in the immature brain plays a key role in the development...

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Detalles Bibliográficos
Autores principales: Kotajima-Murakami, Hiroko, Hagihara, Hideo, Sato, Atsushi, Hagino, Yoko, Tanaka, Miho, Katoh, Yoshihisa, Nishito, Yasumasa, Takamatsu, Yukio, Uchino, Shigeo, Miyakawa, Tsuyoshi, Ikeda, Kazutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850354/
https://www.ncbi.nlm.nih.gov/pubmed/35185658
http://dx.doi.org/10.3389/fpsyt.2022.821354