Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model

Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse model of AD and whether this is correlated wit...

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Detalles Bibliográficos
Autores principales: Aldabbagh, Yousif, Islam, Anam, Zhang, Weicong, Whiting, Paul, Ali, Afia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850407/
https://www.ncbi.nlm.nih.gov/pubmed/35185574
http://dx.doi.org/10.3389/fphar.2022.822499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850407/
https://www.ncbi.nlm.nih.gov/pubmed/35185574
http://dx.doi.org/10.3389/fphar.2022.822499

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