Cargando…

Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model

Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse model of AD and whether this is correlated wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aldabbagh, Yousif, Islam, Anam, Zhang, Weicong, Whiting, Paul, Ali, Afia B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850407/ https://www.ncbi.nlm.nih.gov/pubmed/35185574 http://dx.doi.org/10.3389/fphar.2022.822499

Ejemplares similares

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease
por: Islam, Anam, et al.
Publicado: (2023)

The fate of interneurons, GABA(A) receptor sub‐types and perineuronal nets in Alzheimer's disease
por: Ali, Afia B., et al.
Publicado: (2022)

Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus
por: Chun, Heejung, et al.
Publicado: (2018)

Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
por: Lee, Jung Moo, et al.
Publicado: (2022)

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock‐in rats with increased β‐cleavage of APP
por: Tambini, Marc D., et al.
Publicado: (2019)

The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum
por: Yoon, Bo-Eun, et al.
Publicado: (2011)

Sex-dependent sensitivity to positive allosteric modulation of GABA action in an APP knock-in mouse model of Alzheimer's disease: Potential epigenetic regulation
por: Auta, James, et al.
Publicado: (2021)

Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer’s Disease
por: Narukawa, Masataka, et al.
Publicado: (2020)

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
por: Kersanté, Flavie, et al.
Publicado: (2013)

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
por: Jiang, Richeng, et al.
Publicado: (2022)

Astrocytic GABA transporter activity modulates excitatory neurotransmission
por: Boddum, Kim, et al.
Publicado: (2016)

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes
por: Steardo, Luca, et al.
Publicado: (2015)

Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease
por: Morrissey, Zachery D., et al.
Publicado: (2023)

Enhanced tonic GABA(A) inhibition in typical absence epilepsy
por: Cope, David W., et al.
Publicado: (2009)

Reduced tonic inhibition in striatal output neurons from Huntington mice due to loss of astrocytic GABA release through GAT-3
por: Wójtowicz, Anna M., et al.
Publicado: (2013)

Selective Modulation of α5 GABA(A) Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease
por: Petrache, Alexandra L., et al.
Publicado: (2020)

A Gut Feeling about GABA: Focus on GABA(B) Receptors
por: Hyland, Niall P., et al.
Publicado: (2010)

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
por: Webster, Scott J, et al.
Publicado: (2013)

Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer’s disease pathology
por: Jacob, Sofia, et al.
Publicado: (2019)

Amelioration of Alzheimer’s Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model
por: Minamisawa, Mayumi, et al.
Publicado: (2021)

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in α-Cells
por: Jin, Yang, et al.
Publicado: (2013)

Astrocytes convert network excitation to tonic inhibition of neurons
por: Héja, László, et al.
Publicado: (2012)

Glutamate Uptake Triggers Transporter-Mediated GABA Release from Astrocytes
por: Héja, László, et al.
Publicado: (2009)

Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
por: Song, Inseon, et al.
Publicado: (2011)

Extrasynaptic GABA(A) Receptors and Tonic Inhibition in Rat Auditory Thalamus
por: Richardson, Ben D., et al.
Publicado: (2011)

GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
por: Jin, Zhe, et al.
Publicado: (2011)

Methods for recording and measuring tonic GABA(A) receptor-mediated inhibition
por: Bright, Damian P., et al.
Publicado: (2013)

Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
por: Paulsen, Riley T., et al.
Publicado: (2022)

Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4
por: Valenza, Marta, et al.
Publicado: (2020)

GABA release by hippocampal astrocytes
por: Le Meur, Karim, et al.
Publicado: (2012)

Preserved Calretinin Interneurons in an App Model of Alzheimer’s Disease Disrupt Hippocampal Inhibition via Upregulated P2Y1 Purinoreceptors
por: Shi, Anqi, et al.
Publicado: (2020)

Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease
por: Emre, Ceren, et al.
Publicado: (2021)

Antidepressant activity: contribution of brain microdialysis in knock-out mice to the understanding of BDNF/5-HT transporter/5-HT autoreceptor interactions
por: Gardier, Alain M.
Publicado: (2013)

Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
por: Schipper, S., et al.
Publicado: (2015)

Insulin Regulates GABA(A) Receptor-Mediated Tonic Currents in the Prefrontal Cortex
por: Trujeque-Ramos, Saraí, et al.
Publicado: (2018)

Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors
por: Errington, Adam C., et al.
Publicado: (2011)

Delta-subunit-containing GABA(A)-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala
por: Marowsky, Anne, et al.
Publicado: (2014)

Decreased Glial GABA and Tonic Inhibition in Cerebellum of Mouse Model for Attention-Deficit/Hyperactivity Disorder (ADHD)
por: Kim, Yoo Sung, et al.
Publicado: (2017)

GABA tonic currents and glial cells are altered during epileptogenesis in a mouse model of Dravet syndrome
por: Goisis, Rosa Chiara, et al.
Publicado: (2022)

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex
por: Lalo, Ulyana, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vo7p701t44lpddumeop5am8ku2