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Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA

The existence of non-canonical nicotinamide adenine diphosphate (NAD) 5′-end capped RNAs is now well established. Nevertheless, the biological function of this nucleotide metabolite cap remains elusive. Here, we show that the yeast Saccharomyces cerevisiae cytoplasmic 5′-end exoribonuclease Xrn1 is...

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Detalles Bibliográficos
Autores principales: Sharma, Sunny, Yang, Jun, Grudzien-Nogalska, Ewa, Shivas, Jessica, Kwan, Kelvin Y., Kiledjian, Megerditch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850482/
https://www.ncbi.nlm.nih.gov/pubmed/35173156
http://dx.doi.org/10.1038/s41467-022-28555-7