Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test

Humans are exposed to low levels of N-nitrosamines via different sources. N-Nitrosamines have recently been detected as impurities in various marketed drugs and they are known mutagenic carcinogens belonging to the cohort of concern as referred to in the ICH M7 guideline. Despite their well-known mu...

Descripción completa

Detalles Bibliográficos
Autores principales: Bringezu, Frank, Simon, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850549/
https://www.ncbi.nlm.nih.gov/pubmed/35198408
http://dx.doi.org/10.1016/j.toxrep.2022.02.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850549/
https://www.ncbi.nlm.nih.gov/pubmed/35198408
http://dx.doi.org/10.1016/j.toxrep.2022.02.005

Ejemplares similares