A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway

Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endop...

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Autores principales: Han, Dongjian, Wang, Fuhang, Wang, Bo, Qiao, Zhentao, Cui, Xinyue, Zhang, Yi, Jiang, Qingjiao, Liu, Miaomiao, Shangguan, Jiahong, Zheng, Xiaohui, Bai, Yajun, Du, Chunyan, Shen, Deliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850779/
https://www.ncbi.nlm.nih.gov/pubmed/35185583
http://dx.doi.org/10.3389/fphar.2022.830763
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author Han, Dongjian
Wang, Fuhang
Wang, Bo
Qiao, Zhentao
Cui, Xinyue
Zhang, Yi
Jiang, Qingjiao
Liu, Miaomiao
Shangguan, Jiahong
Zheng, Xiaohui
Bai, Yajun
Du, Chunyan
Shen, Deliang
author_facet Han, Dongjian
Wang, Fuhang
Wang, Bo
Qiao, Zhentao
Cui, Xinyue
Zhang, Yi
Jiang, Qingjiao
Liu, Miaomiao
Shangguan, Jiahong
Zheng, Xiaohui
Bai, Yajun
Du, Chunyan
Shen, Deliang
author_sort Han, Dongjian
collection PubMed
description Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endoplasmic reticulum (ER) stress. A hypertrophic model was established in rats using transverse-aortic constriction (TAC) surgery and in neonatal rat cardiomyocytes (NRCMs) using angiotensin II (Ang II). Our results revealed that DBZ remarkably inhibited oxidative stress and ER stress, blocked autophagy flow, and decreased apoptosis in vivo and in vitro through nuclear NRF2 accumulation, and enhanced NRF2 stability via regulating the mTOR/β-TrcP/NRF2 signal pathway. Thus, DBZ may serve as a promising therapeutic for stress-induced cardiac hypertrophy.
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spelling pubmed-88507792022-02-18 A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway Han, Dongjian Wang, Fuhang Wang, Bo Qiao, Zhentao Cui, Xinyue Zhang, Yi Jiang, Qingjiao Liu, Miaomiao Shangguan, Jiahong Zheng, Xiaohui Bai, Yajun Du, Chunyan Shen, Deliang Front Pharmacol Pharmacology Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects. However, its effects on cardiac hypertrophy are not well understood. In this work, we investigated the treatment effects and potential mechanisms of DBZ on the hypertrophic heart under oxidative stress and endoplasmic reticulum (ER) stress. A hypertrophic model was established in rats using transverse-aortic constriction (TAC) surgery and in neonatal rat cardiomyocytes (NRCMs) using angiotensin II (Ang II). Our results revealed that DBZ remarkably inhibited oxidative stress and ER stress, blocked autophagy flow, and decreased apoptosis in vivo and in vitro through nuclear NRF2 accumulation, and enhanced NRF2 stability via regulating the mTOR/β-TrcP/NRF2 signal pathway. Thus, DBZ may serve as a promising therapeutic for stress-induced cardiac hypertrophy. Frontiers Media S.A. 2022-02-03 /pmc/articles/PMC8850779/ /pubmed/35185583 http://dx.doi.org/10.3389/fphar.2022.830763 Text en Copyright © 2022 Han, Wang, Wang, Qiao, Cui, Zhang, Jiang, Liu, Shangguan, Zheng, Bai, Du and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Han, Dongjian
Wang, Fuhang
Wang, Bo
Qiao, Zhentao
Cui, Xinyue
Zhang, Yi
Jiang, Qingjiao
Liu, Miaomiao
Shangguan, Jiahong
Zheng, Xiaohui
Bai, Yajun
Du, Chunyan
Shen, Deliang
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title_full A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title_fullStr A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title_full_unstemmed A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title_short A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway
title_sort novel compound, tanshinol borneol ester, ameliorates pressure overload-induced cardiac hypertrophy by inhibiting oxidative stress via the mtor/β-trcp/nrf2 pathway
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850779/
https://www.ncbi.nlm.nih.gov/pubmed/35185583
http://dx.doi.org/10.3389/fphar.2022.830763
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