Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance

The appearance of drug-resistant mutations in UL54 DNA polymerase and UL97 kinase genes is problematic for the treatment of human cytomegalovirus (HCMV) diseases. During treatment of HCMV infection in a pediatric hematopoietic cell transplant recipient, H600L and T700A mutations and E576G mutation w...

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Detalles Bibliográficos
Autores principales: Park, Kye Ryeong, Kim, Young-Eui, Shamim, Amen, Gong, Shuang, Choi, Soo-Han, Kim, Kyeong Kyu, Kim, Yae-Jean, Ahn, Jin-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851065/
https://www.ncbi.nlm.nih.gov/pubmed/35185843
http://dx.doi.org/10.3389/fmicb.2022.771978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851065/
https://www.ncbi.nlm.nih.gov/pubmed/35185843
http://dx.doi.org/10.3389/fmicb.2022.771978

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