Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency

Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible CreER-loxP system with superior labeling char...

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Detalles Bibliográficos
Autores principales: Chen, Mianqiao, Tian, Xiong, Xu, Liqun, Wu, Ruolan, He, Haoming, Zhu, Haibao, Xu, Wencan, Wei, Chi-ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851158/
https://www.ncbi.nlm.nih.gov/pubmed/35228901
http://dx.doi.org/10.1016/j.omtn.2022.01.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851158/
https://www.ncbi.nlm.nih.gov/pubmed/35228901
http://dx.doi.org/10.1016/j.omtn.2022.01.022

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