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Membrane tethering of CreER decreases uninduced cell labeling and cytotoxicity while maintaining recombination efficiency
Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible CreER-loxP system with superior labeling char...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851158/ https://www.ncbi.nlm.nih.gov/pubmed/35228901 http://dx.doi.org/10.1016/j.omtn.2022.01.022 |