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Expanded substrate specificity supported by P1′ and P2′ residues enables bacterial dipeptidyl-peptidase 7 to degrade bioactive peptides
Dipeptide production from extracellular proteins is crucial for Porphyromonas gingivalis, a pathogen related to chronic periodontitis, because its energy production is entirely dependent on the metabolism of amino acids predominantly incorporated as dipeptides. These dipeptides are produced by perip...
Autores principales: | Ohara-Nemoto, Yuko, Shimoyama, Yu, Ono, Toshio, Sarwar, Mohammad Tanvir, Nakasato, Manami, Sasaki, Minoru, Nemoto, Takayuki K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851246/ https://www.ncbi.nlm.nih.gov/pubmed/35032549 http://dx.doi.org/10.1016/j.jbc.2022.101585 |
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