Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types

Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent cells. We utilized single-cell RNA sequencing to identify CRY...

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Detalles Bibliográficos
Autores principales: Limbad, Chandani, Doi, Ryosuke, McGirr, Julia, Ciotlos, Serban, Perez, Kevin, Clayton, Zachary S., Daya, Radha, Seals, Douglas R., Campisi, Judith, Melov, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851282/
https://www.ncbi.nlm.nih.gov/pubmed/35198901
http://dx.doi.org/10.1016/j.isci.2022.103848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851282/
https://www.ncbi.nlm.nih.gov/pubmed/35198901
http://dx.doi.org/10.1016/j.isci.2022.103848

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