Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes

CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs. CYP3A4 is involved in the metabolism of 50% of drugs on the market, whereas CYP2D6 is involved in the metabolism of 25% of them. CYP2D6 exhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Okuyama, Shota, Mine, Akari, Nakamura, Teppei, Ohasi, Yusuke, Seto, Mayuko, Tada, Masako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851295/
https://www.ncbi.nlm.nih.gov/pubmed/35174659
http://dx.doi.org/10.1002/prp2.939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851295/
https://www.ncbi.nlm.nih.gov/pubmed/35174659
http://dx.doi.org/10.1002/prp2.939

Ejemplares similares