Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome

Dravet syndrome (DS) is one of the most severe childhood epilepsies, characterized by intractable seizures and comorbidities including cognitive and social dysfunction and high premature mortality. DS is mainly caused by loss-of-function mutations in the Scn1a gene encoding Na(v)1.1 that is predomin...

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Detalles Bibliográficos
Autores principales: Gu, Feng, Parada, Isabel, Yang, Tao, Longo, Frank M., Prince, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851461/
https://www.ncbi.nlm.nih.gov/pubmed/35165147
http://dx.doi.org/10.1073/pnas.2022726119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851461/
https://www.ncbi.nlm.nih.gov/pubmed/35165147
http://dx.doi.org/10.1073/pnas.2022726119

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