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Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome
Dravet syndrome (DS) is one of the most severe childhood epilepsies, characterized by intractable seizures and comorbidities including cognitive and social dysfunction and high premature mortality. DS is mainly caused by loss-of-function mutations in the Scn1a gene encoding Na(v)1.1 that is predomin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851461/ https://www.ncbi.nlm.nih.gov/pubmed/35165147 http://dx.doi.org/10.1073/pnas.2022726119 |