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Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides

Aminoacylated transfer RNAs, which harbor a covalent linkage between amino acids and RNA, are a universally conserved feature of life. Because they are essential substrates for ribosomal translation, aminoacylated oligonucleotides must have been present in the RNA world prior to the evolution of the...

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Detalles Bibliográficos
Autores principales: Radakovic, Aleksandar, DasGupta, Saurja, Wright, Tom H., Aitken, Harry R. M., Szostak, Jack W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851484/
https://www.ncbi.nlm.nih.gov/pubmed/35140183
http://dx.doi.org/10.1073/pnas.2116840119