Protein kinase Cγ in cerebellar Purkinje cells regulates Ca(2+)-activated large-conductance K(+) channels and motor coordination

The cerebellum, the site where protein kinase C (PKC) was first discovered, contains the highest amount of PKC in the central nervous system, with PKCγ being the major isoform. Systemic PKCγ-knockout (KO) mice showed impaired motor coordination and deficient pruning of surplus climbing fibers (CFs)...

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Detalles Bibliográficos
Autores principales: Watanave, Masashi, Takahashi, Nobutaka, Hosoi, Nobutake, Konno, Ayumu, Yamamoto, Hikaru, Yasui, Hiroyuki, Kawachi, Mika, Horii, Takuro, Matsuzaki, Yasunori, Hatada, Izuho, Hirai, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851492/
https://www.ncbi.nlm.nih.gov/pubmed/35145028
http://dx.doi.org/10.1073/pnas.2113336119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851492/
https://www.ncbi.nlm.nih.gov/pubmed/35145028
http://dx.doi.org/10.1073/pnas.2113336119

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