Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release

How can exactly six SNARE complexes be assembled under each synaptic vesicle? Here we report cryo-EM crystal structures of the core domain of Munc13, the key chaperone that initiates SNAREpin assembly. The functional core of Munc13, consisting of C1–C2B–MUN–C2C (Munc13C) spontaneously crystallizes b...

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Detalles Bibliográficos
Autores principales: Grushin, Kirill, Kalyana Sundaram, R. Venkat, Sindelar, Charles V., Rothman, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851502/
https://www.ncbi.nlm.nih.gov/pubmed/35135883
http://dx.doi.org/10.1073/pnas.2121259119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851502/
https://www.ncbi.nlm.nih.gov/pubmed/35135883
http://dx.doi.org/10.1073/pnas.2121259119

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