Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells

A high extracellular adenosine triphosphate (ATP) concentration rapidly and reversibly exposes phosphatidylserine (PtdSer) in T cells by binding to the P2X7 receptor, which ultimately leads to necrosis. Using mouse T cell transformants expressing P2X7, we herein performed CRISPR/Cas9 screening for t...

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Detalles Bibliográficos
Autores principales: Ryoden, Yuta, Segawa, Katsumori, Nagata, Shigekazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851519/
https://www.ncbi.nlm.nih.gov/pubmed/35140185
http://dx.doi.org/10.1073/pnas.2119286119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851519/
https://www.ncbi.nlm.nih.gov/pubmed/35140185
http://dx.doi.org/10.1073/pnas.2119286119

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