Disrupted Cacna1c gene expression perturbs spontaneous Ca(2+) activity causing abnormal brain development and increased anxiety

The L-type voltage-gated Ca(2+) channel gene CACNA1C is a risk gene for various psychiatric conditions, including schizophrenia and bipolar disorder. However, the cellular mechanism by which CACNA1C contributes to psychiatric disorders has not been elucidated. Here, we report that the embryonic dele...

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Detalles Bibliográficos
Autores principales: Smedler, Erik, Louhivuori, Lauri, Romanov, Roman A., Masini, Débora, Dehnisch Ellström, Ivar, Wang, Chungliang, Caramia, Martino, West, Zoe, Zhang, Songbai, Rebellato, Paola, Malmersjö, Seth, Brusini, Irene, Kanatani, Shigeaki, Fisone, Gilberto, Harkany, Tibor, Uhlén, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851547/
https://www.ncbi.nlm.nih.gov/pubmed/35135875
http://dx.doi.org/10.1073/pnas.2108768119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851547/
https://www.ncbi.nlm.nih.gov/pubmed/35135875
http://dx.doi.org/10.1073/pnas.2108768119

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