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Disrupted Cacna1c gene expression perturbs spontaneous Ca(2+) activity causing abnormal brain development and increased anxiety
The L-type voltage-gated Ca(2+) channel gene CACNA1C is a risk gene for various psychiatric conditions, including schizophrenia and bipolar disorder. However, the cellular mechanism by which CACNA1C contributes to psychiatric disorders has not been elucidated. Here, we report that the embryonic dele...
Autores principales: | Smedler, Erik, Louhivuori, Lauri, Romanov, Roman A., Masini, Débora, Dehnisch Ellström, Ivar, Wang, Chungliang, Caramia, Martino, West, Zoe, Zhang, Songbai, Rebellato, Paola, Malmersjö, Seth, Brusini, Irene, Kanatani, Shigeaki, Fisone, Gilberto, Harkany, Tibor, Uhlén, Per |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851547/ https://www.ncbi.nlm.nih.gov/pubmed/35135875 http://dx.doi.org/10.1073/pnas.2108768119 |
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