Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer

Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder cancer (BCa). Although known as a tumor suppressor, KDM6A’s therapeutic potential in the metastasis of BCa remains elusive. It also remains difficult to fulfill the effective up-regulation of KDM6A levels in bla...

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Detalles Bibliográficos
Autores principales: Kong, Na, Zhang, Ruonan, Wu, Gongwei, Sui, Xinbing, Wang, Junqing, Kim, Na Yoon, Blake, Sara, De, Diba, Xie, Tian, Cao, Yihai, Tao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851555/
https://www.ncbi.nlm.nih.gov/pubmed/35131941
http://dx.doi.org/10.1073/pnas.2112696119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851555/
https://www.ncbi.nlm.nih.gov/pubmed/35131941
http://dx.doi.org/10.1073/pnas.2112696119

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