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Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver

The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized. Here, we...

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Detalles Bibliográficos
Autores principales: Bideyan, Lara, Fan, Wenxin, Kaczor-Urbanowicz, Karolina Elżbieta, Priest, Christina, Casero, David, Tontonoz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851562/
https://www.ncbi.nlm.nih.gov/pubmed/35145035
http://dx.doi.org/10.1073/pnas.2122683119