Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1

Immune evasion is a significant contributor to tumor evolution, and the immunoinhibitory axis PD-1/PD-L1 is a frequent mechanism employed to escape tumor immune surveillance. To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating...

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Detalles Bibliográficos
Autores principales: Oreskovic, Ena, Wheeler, Emily C., Mengwasser, Kristen E., Fujimura, Eric, Martin, Timothy D., Tothova, Zuzana, Elledge, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851563/
https://www.ncbi.nlm.nih.gov/pubmed/35149558
http://dx.doi.org/10.1073/pnas.2120540119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851563/
https://www.ncbi.nlm.nih.gov/pubmed/35149558
http://dx.doi.org/10.1073/pnas.2120540119

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