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Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1

Immune evasion is a significant contributor to tumor evolution, and the immunoinhibitory axis PD-1/PD-L1 is a frequent mechanism employed to escape tumor immune surveillance. To identify cancer drivers involved in immune evasion, we performed a CRISPR-Cas9 screen of tumor suppressor genes regulating...

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Detalles Bibliográficos
Autores principales:	Oreskovic, Ena, Wheeler, Emily C., Mengwasser, Kristen E., Fujimura, Eric, Martin, Timothy D., Tothova, Zuzana, Elledge, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851563/ https://www.ncbi.nlm.nih.gov/pubmed/35149558 http://dx.doi.org/10.1073/pnas.2120540119

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