Inhibiting KDM6A Demethylase Represses Long Non-Coding RNA Hotairm1 Transcription in MDSC During Sepsis

Myeloid-derived suppressor cells (MDSCs) prolong sepsis by promoting immunosuppression. We reported that sepsis MDSC development requires long non-coding RNA Hotairm1 interactions with S100A9. Using a mouse model that simulates the immunobiology of sepsis, we find that histone demethylase KDM6A prom...

Descripción completa

Detalles Bibliográficos
Autores principales: Bah, Isatou, Youssef, Dima, Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851568/
https://www.ncbi.nlm.nih.gov/pubmed/35185915
http://dx.doi.org/10.3389/fimmu.2022.823660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851568/
https://www.ncbi.nlm.nih.gov/pubmed/35185915
http://dx.doi.org/10.3389/fimmu.2022.823660

Ejemplares similares