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Inhibiting KDM6A Demethylase Represses Long Non-Coding RNA Hotairm1 Transcription in MDSC During Sepsis

Myeloid-derived suppressor cells (MDSCs) prolong sepsis by promoting immunosuppression. We reported that sepsis MDSC development requires long non-coding RNA Hotairm1 interactions with S100A9. Using a mouse model that simulates the immunobiology of sepsis, we find that histone demethylase KDM6A prom...

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Detalles Bibliográficos
Autores principales:	Bah, Isatou, Youssef, Dima, Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851568/ https://www.ncbi.nlm.nih.gov/pubmed/35185915 http://dx.doi.org/10.3389/fimmu.2022.823660

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