A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity

Hepatic lipid accumulation is a hallmark of type II diabetes (T2D) associated with hyperinsulinemia, insulin resistance, and hyperphagia. Hepatic synthesis of GABA, catalyzed by GABA-transaminase (GABA-T), is upregulated in obese mice. To assess the role of hepatic GABA production in obesity-induced...

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Detalles Bibliográficos
Autores principales: Geisler, Caroline E., Ghimire, Susma, Bruggink, Stephanie M., Miller, Kendra E., Weninger, Savanna N., Kronenfeld, Jason M., Yoshino, Jun, Klein, Samuel, Duca, Frank A., Renquist, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851954/
https://www.ncbi.nlm.nih.gov/pubmed/34192532
http://dx.doi.org/10.1016/j.celrep.2021.109301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851954/
https://www.ncbi.nlm.nih.gov/pubmed/34192532
http://dx.doi.org/10.1016/j.celrep.2021.109301

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