Pharmacological evaluation of disulfiram analogs as antimicrobial agents and their application as inhibitors of fosB-mediated fosfomycin resistance

Disulfide analogs of the alcohol sobriety medication disulfiram (Antabuse(™)) were evaluated for antimicrobial activity. Structure-activity relationship analyses of MIC data obtained for MRSA and other pathogenic organisms revealed correlations between the lipophilicity and bulkiness of the substitu...

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Detalles Bibliográficos
Autores principales: Lewis, Alexandria D., Riedel, Taylor M., Kesler, Meredith B.A., Varney, Melinda E., Long, Timothy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852335/
https://www.ncbi.nlm.nih.gov/pubmed/35058577
http://dx.doi.org/10.1038/s41429-022-00500-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852335/
https://www.ncbi.nlm.nih.gov/pubmed/35058577
http://dx.doi.org/10.1038/s41429-022-00500-2

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