Differing pan-coronavirus antiviral potency of boceprevir and GC376 in vitro despite discordant molecular docking predictions

Given the structural similarities of the viral enzymes of different coronaviruses (CoVs), we investigated the potency of the anti-SARS-CoV-2 agents boceprevir and GC376 for counteracting seasonal coronavirus infections. In contrast to previous findings that both boceprevir and GC376 are potent inhib...

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Detalles Bibliográficos
Autores principales: Wang, Yining, Li, Pengfei, Lavrijsen, Marla, Li, Yang, Ma, Zhongren, Peppelenbosch, Maikel P., Baig, Mirza S., Pan, Qiuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853085/
https://www.ncbi.nlm.nih.gov/pubmed/35171357
http://dx.doi.org/10.1007/s00705-022-05369-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853085/
https://www.ncbi.nlm.nih.gov/pubmed/35171357
http://dx.doi.org/10.1007/s00705-022-05369-y

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