A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5, and 7 but not Hdac9. Here, we show that a transcription factor regulated genetic compensatory mechanism within this family of proteins, blocks negati...

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Detalles Bibliográficos
Autores principales: Velasco-Aviles, Sergio, Patel, Nikiben, Casillas-Bajo, Angeles, Frutos-Rincón, Laura, Velasco, Enrique, Gallar, Juana, Arthur-Farraj, Peter, Gomez-Sanchez, Jose A, Cabedo, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853665/
https://www.ncbi.nlm.nih.gov/pubmed/35076395
http://dx.doi.org/10.7554/eLife.72917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853665/
https://www.ncbi.nlm.nih.gov/pubmed/35076395
http://dx.doi.org/10.7554/eLife.72917

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