Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma

Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer. In cutaneous melanoma, a cancer with one of the high levels of Hsp90 overexpression, such expression was correlated with a panel of protein kinases, thus offering an opportunity to identify Hsp90-based multi-kinase...

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Detalles Bibliográficos
Autores principales: Qin, Feifei, Wang, Yali, Jiang, Xian, Wang, Yujia, Zhang, Nan, Wen, Xiang, Wang, Lian, Jiang, Qinglin, He, Gu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853710/
https://www.ncbi.nlm.nih.gov/pubmed/30957641
http://dx.doi.org/10.1080/14756366.2019.1596903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853710/
https://www.ncbi.nlm.nih.gov/pubmed/30957641
http://dx.doi.org/10.1080/14756366.2019.1596903

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