Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in the blood and is associated with a reduced immunogenicity. As antigen presentation is a primary event in the activation of CD4 T-cells and initiation of Anti-Drug Antibody (ADA) response, we investigated the...

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Detalles Bibliográficos
Autores principales: de Bourayne, Marie, Meunier, Sylvain, Bitoun, Samuel, Correia, Evelyne, Mariette, Xavier, Nozach, Hervé, Maillère, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854214/
https://www.ncbi.nlm.nih.gov/pubmed/35185895
http://dx.doi.org/10.3389/fimmu.2022.808606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854214/
https://www.ncbi.nlm.nih.gov/pubmed/35185895
http://dx.doi.org/10.3389/fimmu.2022.808606

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