A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening

The main protease (M(pro)) and papain‐like protease (PL(pro)) play critical roles in SARS‐CoV‐2 replication and are promising targets for antiviral inhibitors. The simultaneous visualization of M(pro) and PL(pro) is extremely valuable for SARS‐CoV‐2 detection and rapid inhibitor screening. However,...

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Detalles Bibliográficos
Autores principales: Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854376/
https://www.ncbi.nlm.nih.gov/pubmed/34889013
http://dx.doi.org/10.1002/anie.202113617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854376/
https://www.ncbi.nlm.nih.gov/pubmed/34889013
http://dx.doi.org/10.1002/anie.202113617

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