TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into ovarian follicles, activates TrkB signaling, and promotes ovary development. In...

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Detalles Bibliográficos
Autores principales: Qin, Xunsi, Zhao, Yue, Zhang, Tianyi, Yin, Chenghong, Qiao, Jie, Guo, Wei, Lu, Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854395/
https://www.ncbi.nlm.nih.gov/pubmed/35177657
http://dx.doi.org/10.1038/s41467-022-28611-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854395/
https://www.ncbi.nlm.nih.gov/pubmed/35177657
http://dx.doi.org/10.1038/s41467-022-28611-2

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