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A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions
Cyclic GMP-AMP synthase (cGAS) recognizes double-stranded DNA (dsDNA) derived from invading pathogens and induces an interferon response via activation of the key downstream adaptor protein stimulator of interferon genes (STING). This is the most classic biological function of the cGAS-STING signali...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854490/ https://www.ncbi.nlm.nih.gov/pubmed/35185917 http://dx.doi.org/10.3389/fimmu.2022.826880 |