RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity

The 53BP1-RIF1 pathway antagonizes resection of DNA broken ends and confers PARP inhibitor sensitivity on BRCA1-mutated tumors. However, it is unclear how this pathway suppresses initiation of resection. Here, we identify ASF1 as a partner of RIF1 via an interacting manner similar to its interaction...

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Detalles Bibliográficos
Autores principales: Feng, Sumin, Ma, Sai, Li, Kejiao, Gao, Shengxian, Ning, Shaokai, Shang, Jinfeng, Guo, Ruiyuan, Chen, Yingying, Blumenfeld, Britny, Simon, Itamar, Li, Qing, Guo, Rong, Xu, Dongyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854732/
https://www.ncbi.nlm.nih.gov/pubmed/35177609
http://dx.doi.org/10.1038/s41467-022-28588-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854732/
https://www.ncbi.nlm.nih.gov/pubmed/35177609
http://dx.doi.org/10.1038/s41467-022-28588-y

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