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Topological data analysis gives two folding paths in HP35(nle-nle), double mutant of villin headpiece subdomain

The folding dynamics of proteins is a primary area of interest in protein science. We carried out topological data analysis (TDA) of the folding process of HP35(nle-nle), a double-mutant of the villin headpiece subdomain. Using persistent homology and non-negative matrix factorization, we reduced th...

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Detalles Bibliográficos
Autor principal: Ichinomiya, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854739/
https://www.ncbi.nlm.nih.gov/pubmed/35177744
http://dx.doi.org/10.1038/s41598-022-06682-x