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Topological data analysis gives two folding paths in HP35(nle-nle), double mutant of villin headpiece subdomain
The folding dynamics of proteins is a primary area of interest in protein science. We carried out topological data analysis (TDA) of the folding process of HP35(nle-nle), a double-mutant of the villin headpiece subdomain. Using persistent homology and non-negative matrix factorization, we reduced th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854739/ https://www.ncbi.nlm.nih.gov/pubmed/35177744 http://dx.doi.org/10.1038/s41598-022-06682-x |