Cargando…

A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease

Cellular models recapitulating features of tauopathies are useful tools to investigate the causes and consequences of tau aggregation and the identification of novel treatments. We seeded rat primary cortical neurons with tau isolated from Alzheimer’s disease brains to induce a time-dependent increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ficulle, Elena, Kananathan, Sarubini, Airey, David, Gharbi, Severine I., Humphryes-Kirilov, Neil, Scherschel, James, Dunbar, Charlotte, Eastwood, Brian J., Laing, Emma, Collier, David A., Bose, Suchira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854741/ https://www.ncbi.nlm.nih.gov/pubmed/35177665 http://dx.doi.org/10.1038/s41598-022-06411-4

Ejemplares similares

Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b
por: Hosseini-Gerami, Layla, et al.
Publicado: (2023)

Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures
por: Katsikoudi, Antigoni, et al.
Publicado: (2020)

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model
por: Wang, Hong, et al.
Publicado: (2018)

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates
por: Falcon, Benjamin, et al.
Publicado: (2015)

Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
por: Le, Ly Thi Huong Luu, et al.
Publicado: (2023)

Human tau-overexpressing mice recapitulate brainstem involvement and neuropsychiatric features of early Alzheimer’s disease
por: Khan, Kanza M., et al.
Publicado: (2023)

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
por: Frey, Bryan, et al.
Publicado: (2023)

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
por: DeVos, Sarah L., et al.
Publicado: (2018)

Desktop Genetics
por: Hough, Soren H, et al.
Publicado: (2016)

Trans‐seeding of Alzheimer‐related tau protein by a yeast prion
por: Flach, Martin, et al.
Publicado: (2022)

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease
por: Hopp, Sarah C., et al.
Publicado: (2018)

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease
por: Meisl, Georg, et al.
Publicado: (2021)

In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer’s brain
por: Nam, Won-Hee, et al.
Publicado: (2018)

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β
por: Nies, Sarah Helena, et al.
Publicado: (2021)

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
por: Janelidze, Shorena, et al.
Publicado: (2020)

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
por: Kraus, Allison, et al.
Publicado: (2018)

Ultrasensitive tau biosensor cells detect no seeding in Alzheimer’s disease CSF
por: Hitt, Brian D., et al.
Publicado: (2021)

RNA induces unique tau strains and stabilizes Alzheimer’s disease seeds
por: Zwierzchowski-Zarate, Amy N., et al.
Publicado: (2022)

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils
por: Abskharon, Romany, et al.
Publicado: (2023)

Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
por: Manca, Matteo, et al.
Publicado: (2023)

Recapitulation
Publicado: (1866)

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART
por: Kaufman, Sarah K., et al.
Publicado: (2018)

Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer’s Brain
por: Wu, Ruozhen, et al.
Publicado: (2021)

PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
por: Soares, Alberto Carpinteiro, et al.
Publicado: (2021)

Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study
por: Brickman, Adam M., et al.
Publicado: (2021)

Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta
por: Miyoshi, Emily, et al.
Publicado: (2021)

Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
por: Malcolm, Janice C., et al.
Publicado: (2019)

Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice
por: Dai, Chun-ling, et al.
Publicado: (2018)

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities
por: Parent, Maxime J., et al.
Publicado: (2017)

Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments
por: Hough, Soren H., et al.
Publicado: (2017)

Erratum to: Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments
por: Hough, Soren H., et al.
Publicado: (2017)

Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease
por: Zhang, Guoxin, et al.
Publicado: (2022)

Plasma tau in Alzheimer disease
por: Mattsson, Niklas, et al.
Publicado: (2016)

Concatenating plasma p-tau to Alzheimer’s disease
por: Tijms, Betty M, et al.
Publicado: (2021)

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes
por: Marquer, Catherine, et al.
Publicado: (2014)

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
por: Danis, Clément, et al.
Publicado: (2022)

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells
por: Lathuiliere, Aurelien, et al.
Publicado: (2023)

Plasma tau levels in Alzheimer's disease
por: Zetterberg, Henrik, et al.
Publicado: (2013)

Cerebrovascular disease promotes tau pathology in Alzheimer’s disease
por: Laing, Krystal K, et al.
Publicado: (2020)

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration
por: Thijssen, Elisabeth H., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3kffdmq8hcp7iahoh34t5baa74