Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally) was given to rats for 10 days, with or without M...

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Detalles Bibliográficos
Autores principales: Morsy, Mohamed A., El-Sheikh, Azza A. K., Abdel-Hafez, Sara Mohamed Naguib, Kandeel, Mahmoud, Abdel-Gaber, Seham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854802/
https://www.ncbi.nlm.nih.gov/pubmed/35185559
http://dx.doi.org/10.3389/fphar.2022.774387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8854802/
https://www.ncbi.nlm.nih.gov/pubmed/35185559
http://dx.doi.org/10.3389/fphar.2022.774387

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