Proposed Mechanism for the Biosynthesis of the [FeFe] Hydrogenase H-Cluster: Central Roles for the Radical SAM Enzymes HydG and HydE

[Image: see text] Radical S-adenosylmethionine (radical SAM or rSAM) enzymes use their S-adenosylmethionine cofactor bound to a unique Fe of a [4Fe–4S] cluster to generate the “hot” 5′-deoxyadenosyl radical, which drives highly selective radical reactions via specific interactions with a given rSAM...

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Detalles Bibliográficos
Autores principales: Britt, R. David, Tao, Lizhi, Rao, Guodong, Chen, Nanhao, Wang, Lee-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855341/
https://www.ncbi.nlm.nih.gov/pubmed/35187536
http://dx.doi.org/10.1021/acsbiomedchemau.1c00035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855341/
https://www.ncbi.nlm.nih.gov/pubmed/35187536
http://dx.doi.org/10.1021/acsbiomedchemau.1c00035

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