Molecular Basis of Small-Molecule Binding to α-Synuclein

[Image: see text] Intrinsically disordered proteins (IDPs) are implicated in many human diseases. They have generally not been amenable to conventional structure-based drug design, however, because their intrinsic conformational variability has precluded an atomic-level understanding of their bindin...

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Detalles Bibliográficos
Autores principales: Robustelli, Paul, Ibanez-de-Opakua, Alain, Campbell-Bezat, Cecily, Giordanetto, Fabrizio, Becker, Stefan, Zweckstetter, Markus, Pan, Albert C., Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855421/
https://www.ncbi.nlm.nih.gov/pubmed/35130691
http://dx.doi.org/10.1021/jacs.1c07591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855421/
https://www.ncbi.nlm.nih.gov/pubmed/35130691
http://dx.doi.org/10.1021/jacs.1c07591

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