Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with Acceptor-Acceptor Carbene Donors

[Image: see text] The biocatalytic toolbox has recently been expanded to include enzyme-catalyzed carbene transfer reactions not occurring in Nature. Herein, we report the development of a biocatalytic strategy for the synthesis of enantioenriched α-trifluoromethyl amines through an asymmetric N–H c...

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Detalles Bibliográficos
Autores principales: Nam, Donggeon, Tinoco, Antonio, Shen, Zhuofan, Adukure, Ronald D., Sreenilayam, Gopeekrishnan, Khare, Sagar D., Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855427/
https://www.ncbi.nlm.nih.gov/pubmed/35107997
http://dx.doi.org/10.1021/jacs.1c10750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855427/
https://www.ncbi.nlm.nih.gov/pubmed/35107997
http://dx.doi.org/10.1021/jacs.1c10750

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