Echinocandin Resistance in Aspergillus fumigatus Has Broad Implications for Membrane Lipid Perturbations That Influence Drug-Target Interactions

Echinocandin drugs target the fungal enzyme β-(1,3)-glucan synthase (GS), which is required for the synthesis of cell wall component β-(1,3)-d-glucan. They are first-line therapy for Candida infections but are increasingly used as second-line therapy for Aspergillus infections. Resistance to echinoc...

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Detalles Bibliográficos
Autores principales: Satish, Shruthi, Perlin, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855445/
https://www.ncbi.nlm.nih.gov/pubmed/35185336
http://dx.doi.org/10.1177/1178636119897034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855445/
https://www.ncbi.nlm.nih.gov/pubmed/35185336
http://dx.doi.org/10.1177/1178636119897034

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