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Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

BACKGROUND: Activins and bone morphogenetic proteins (BMPs) play critical, sometimes opposing roles, in multiple physiological and pathological processes and diseases. They signal to distinct Smad branches; activins signal mainly to Smad2/3, while BMPs activate mainly Smad1/5/8. This gives rise to t...

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Detalles Bibliográficos
Autores principales:	Szilágyi, Szabina Szófia, Amsalem-Zafran, Ayelet R., Shapira, Keren E., Ehrlich, Marcelo, Henis, Yoav I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855587/ https://www.ncbi.nlm.nih.gov/pubmed/35177083 http://dx.doi.org/10.1186/s12915-022-01252-z

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