Hypoxic vasodilatory defect and pulmonary hypertension in mice lacking hemoglobin β-cysteine93 S-nitrosylation

Systemic hypoxia is characterized by peripheral vasodilation and pulmonary vasoconstriction. However, the system-wide mechanism for signaling hypoxia remains unknown. Accumulating evidence suggests that hemoglobin (Hb) in RBCs may serve as an O(2) sensor and O(2)-responsive NO signal transducer to r...

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Detalles Bibliográficos
Autores principales: Zhang, Rongli, Hausladen, Alfred, Qian, Zhaoxia, Liao, Xudong, Premont, Richard T., Stamler, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855790/
https://www.ncbi.nlm.nih.gov/pubmed/34914637
http://dx.doi.org/10.1172/jci.insight.155234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855790/
https://www.ncbi.nlm.nih.gov/pubmed/34914637
http://dx.doi.org/10.1172/jci.insight.155234

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