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Indoxyl sulfate reduces I(to,f) by activating ROS/MAPK and NF-κB signaling pathways

There is a high prevalence of ventricular arrhythmias related to sudden cardiac death in patients with chronic kidney disease (CKD). To explored the possible mechanism of CKD-related ventricular arrhythmias, a CKD rat model was created, and indoxyl sulfate (IS) was further used in vivo and in vitro....

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Detalles Bibliográficos
Autores principales: Yang, Jing, Li, Hongxia, Zhang, Chi, Zhou, Yafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855797/
https://www.ncbi.nlm.nih.gov/pubmed/35132967
http://dx.doi.org/10.1172/jci.insight.145475